Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.71 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.71 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.71 |
| ▸ | EDNRA | P25101 | 1/20 | 0.71 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.68 |
| ▸ | HPGD | P15428 | 7/20 | 0.68 |
| ▸ | TSHR | P16473 | 2/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | BRD4 | O60885 | 1/20 | 0.68 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | TOP2A | P11388 | 1/20 | 0.50 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL9775888 | 0.99 | LMNA (0.70) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL8941879 | 0.90 | LMNA (0.61) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775875 | 0.90 | DRD3 (0.56) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775890 | 0.90 | DRD3 (0.67) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775921 | 0.88 | ALDH1A1 (0.60) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775945 | 0.87 | ALDH1A1 (0.55) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| Water SCHEMBL9785229 | 0.87 | ALDH1A1 (0.54) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| Water SCHEMBL9785232 | 0.87 | ALDH1A1 (0.54) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL9775868 | 0.86 | DRD3 (0.55) | LMNACYP2C9ATP6V1B2TBXA2REDNRA | |
| SCHEMBL7227652 | 0.86 | DRD3 (0.53) | LMNACYP2C9ATP6V1B2TBXA2REDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0379412-B1 | 1,8-Benzonaphthyridine derivatives, their preparation and compositions containing them | BELLON LABOR SA ROGER (FR) | 1993-12-01 | — | — | EP | claimed |
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | claimed |
| US-5004745-A | Benzo[1,8]naphthyridine derivatives, their preparation and the compositions which contain them | LABORATOIRE ROGER BELLON (FR) | 1991-04-02 | — | — | US | disclosed |
| US-4990515-A | Chemical intermediates | RHONE-POULENC SANTE (FR) | 1991-02-05 | — | — | US | disclosed |
| US-4970213-A | Benzo(1,8)naphthyridine derivatives as intermediates | RHONE-POULENC SANTE (FR) | 1990-11-13 | — | — | US | disclosed |