SCHEMBL952977

SCHEMBL952977

COc1ccc(C(=O)c2ccccc2S(=O)(=O)O)c(O)c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 5/20 0.71
HPGD P15428 3/20 0.71
CYP2C19 P33261 3/20 0.71
CYP3A4 P08684 3/20 0.71
CYP1A2 P05177 2/20 0.71
PGR P06401 2/20 0.71
SLC6A2 P23975 2/20 0.71
ADORA3 P0DMS8 1/20 0.71
AR P10275 1/20 0.71
CHRM1 P11229 1/20 0.71
ALOX15 P16050 1/20 0.71
TBXA2R P21731 1/20 0.71
ADRA1A P35348 1/20 0.71
HIF1A Q16665 1/20 0.71
NPC1 O15118 5/20 0.67
RAB9A P51151 5/20 0.67
ALDH1A1 P00352 3/20 0.61
MAPK1 P28482 3/20 0.61
CYP2D6 P10635 1/20 0.61
PDE4A P27815 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL6265053 0.99 LMNA (0.69) LMNAHPGDCYP2C19CYP3A4CYP1A2
SCHEMBL6334068 0.90 NPC1 (0.73) LMNAHPGDCYP2C19CYP3A4CYP1A2
Sulfuric Acid SCHEMBL9740504 0.85 NPC1 (0.86) LMNAHPGDCYP2C19CYP3A4CYP1A2
Dioxybenzone SCHEMBL29354139 0.84 LMNA (1.00) LMNAHPGDCYP2C19CYP3A4CYP1A2
Dioxybenzone SCHEMBL29364693 0.84 LMNA (1.00) LMNAHPGDCYP2C19CYP3A4CYP1A2
Dioxybenzone SCHEMBL29365575 0.84 LMNA (1.00) LMNAHPGDCYP2C19CYP3A4CYP1A2
Dioxybenzone SCHEMBL7936480 0.84 LMNA (1.00) LMNAHPGDCYP2C19CYP3A4CYP1A2
Dioxybenzone SCHEMBL6674075 0.84 LMNA (1.00) LMNAHPGDCYP2C19CYP3A4CYP1A2
Dioxybenzone SCHEMBL15894 0.84 LMNA (1.00) LMNAHPGDCYP2C19CYP3A4CYP1A2
SCHEMBL9762530 0.82 NPC1 (0.65) LMNAHPGDCYP2C19CYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 116 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2258340-B1 HAIR CONDITIONING COMPOSITION KAO CORP (JP) 2017-09-20 EP claimed
US-8932568-B2 Hair conditioning composition KAO CORPORATION (JP) 2015-01-13 US claimed
CN-102099007-B Hair care composition KAO CORP 2013-04-03 CN claimed
CN-102099007-A Hair Care Composition KAO CORP 2011-06-15 CN claimed
US-20110014145-A1 HAIR CONDITIONING COMPOSITION KAO CORPORATION (JP) 2011-01-20 US claimed
EP-2258340-A1 HAIR CONDITIONING COMPOSITION Kao Corporation (JP) 2010-12-08 EP claimed
EP-0931539-B1 Cuticle caring method KAO CORP (JP) 2005-10-19 EP claimed
US-6174523-B1 Hair cuticle caring method KAO CORPORATION (JP) 2001-01-16 US claimed
EP-0931539-A2 Cuticle caring method KAO CORPORATION (JP) 1999-07-28 EP claimed
CN-117597411-A Foamable aerosol composition, foamable aerosol product, and method for suppressing combustibility 株式会社大造 2024-02-23 CN disclosed
CN-107106570-B Aqueous composition 兴和株式会社 2021-02-05 CN disclosed
CN-107106569-B Composition comprising a metal oxide and a metal oxide 兴和株式会社 2020-07-28 CN disclosed
CN-110494138-A Pharmaceutical preparation KOWA CO 2019-11-22 CN disclosed
CN-110381946-A Pharmaceutical preparation 兴和株式会社 2019-10-25 CN disclosed
US-5683685-A NAPHTHALENESULFONIC ACID AND/OR BENZOPHENONE SULFONIC ACID WITH ANIONIC AND/OR AMPHOTERIC SURFACTANT WITH OIL KAO CORPORATION (JP) 1997-11-04 US disclosed
US-5637293-A STABILITY; DISCOLORATION INHIBITION; MIXTURE OF KOJIC ACID, ULTRAVIOLET RADIATION ABSORBER, FATTY ESTER AND(OR) GLYCERIDE SANSHO SEIYAKU CO., LTD. (JP) 1997-06-10 US disclosed
US-5599528-A PREVENTING DISCOLORATION AND DECOMPOSITION OF KOJIC ACID IN AQUEOUS COSMETIC EMULSIONS BY ADDING NONIONIC SURFACTANTS AND CONTROLLING HYDROPHILIC-LIPOPHILIC BALANCE SANSHO SEIYAKU CO., LTD. (JP) 1997-02-04 US disclosed
EP-0743847-A1 HAIR COSMETIC COMPOSITION Kao Corporation (JP) 1996-11-27 EP disclosed
CN-1106659-A Preparation for epidermis and process for its preparation SANSHO SEIYAKU KK (JP) 1995-08-16 CN disclosed
WO-1995020375-A1 HAIR COSMETIC COMPOSITION KAO CORPORATION (JP) 1995-08-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110014145-A1 HAIR CONDITIONING COMPOSITION OR10J3, H1-10, SGMS1 LMNA 1820/4885HPGD 3048/4885CYP2C19 3218/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.