Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | DHODH | Q02127 | 2/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529969 | 0.89 | CYP3A4 (0.57) | CYP3A4DHODHALOX5KDM4EALDH1A1 | |
| SCHEMBL2735411 | 0.87 | MAOA (0.52) | CYP3A4DHODHKDM4EALDH1A1CYP1A2 | |
| SCHEMBL4825992 | 0.83 | CYP3A4 (0.54) | CYP3A4ALOX5KDM4EALDH1A1CYP1A2 | |
| SCHEMBL2131853 | 0.83 | XDH (0.55) | CYP3A4ALOX5KDM4EALDH1A1CYP1A2 | |
| SCHEMBL21905211 | 0.81 | DHODH (0.64) | CYP3A4DHODHALOX5KDM4EALDH1A1 | |
| SCHEMBL30572552 | 0.81 | DHODH (0.64) | CYP3A4DHODHALOX5KDM4EALDH1A1 | |
| SCHEMBL30572513 | 0.81 | DHODH (0.64) | CYP3A4DHODHALOX5KDM4EALDH1A1 | |
| SCHEMBL4470392 | 0.81 | NPC1 (0.52) | CYP3A4ALOX5KDM4EALDH1A1CYP1A2 | |
| SCHEMBL10146397 | 0.80 | HSD17B10 (0.50) | CYP3A4KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7921440 | 0.80 | CYP3A4 (0.48) | CYP3A4ALOX5KDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266326-B1 | NOVEL DERIVATIVES OF BENZIMIDAZOLES ACTIVE AS ANTI-ULCER AGENTS | Aktiebolaget Hässle (SE) | 1993-03-10 | — | — | EP | disclosed |
| US-5106862-A | DERIVATIVES OF BENZIMIDAZOLES ACTIVE AS ANTI-ULCER AGENTS | AKTIEBOLAGET HASSLE (SE) | 1992-04-21 | — | — | US | disclosed |
| EP-0266326-A1 | Novel derivatives of benzimidazoles active as anti-ulcer agents | Aktiebolaget Hässle (SE) | 1988-05-04 | — | — | EP | disclosed |