SCHEMBL9529969

SCHEMBL9529969

Cc1nc2ccc(OCc3ccccc3)cc2[nH]1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 3/20 0.57
CYP2E1 P05181 2/20 0.57
CYP2C8 P10632 2/20 0.57
CYP2D6 P10635 2/20 0.57
CYP2C9 P11712 2/20 0.57
CYP2B6 P20813 2/20 0.57
CYP2C19 P33261 2/20 0.57
FGFR1 P11362 1/20 0.55
FGFR2 P21802 1/20 0.55
FGFR3 P22607 1/20 0.55
MAOA P21397 1/20 0.53
DHODH Q02127 2/20 0.53
RAB9A P51151 3/20 0.52
NPC1 O15118 2/20 0.52
TP53 P04637 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
KDM4E B2RXH2 1/20 0.52
USP2 O75604 1/20 0.52
ALDH1A1 P00352 1/20 0.52
LMNA P02545 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30572513 0.89 DHODH (0.64) CYP3A4CYP2E1CYP2C8CYP2D6CYP2C9
SCHEMBL30572552 0.89 DHODH (0.64) CYP3A4CYP2E1CYP2C8CYP2D6CYP2C9
SCHEMBL21905211 0.89 DHODH (0.64) CYP3A4CYP2E1CYP2C8CYP2D6CYP2C9
SCHEMBL9529962 0.89 CYP3A4 (0.54) CYP3A4CYP2C9MAOADHODHRAB9A
SCHEMBL21905333 0.86 DHODH (0.67) CYP3A4CYP2E1CYP2C8CYP2D6CYP2C9
SCHEMBL30572546 0.86 DHODH (0.67) CYP3A4CYP2E1CYP2C8CYP2D6CYP2C9
SCHEMBL4825999 0.83 CYP3A4 (0.54) CYP3A4CYP2E1CYP2C8CYP2D6CYP2C9
SCHEMBL5679297 0.83 CYP3A4 (0.56) CYP3A4CYP2E1CYP2C8CYP2D6CYP2C9
SCHEMBL5486395 0.81 CTSV (0.61) CYP2C9MAOADHODHRAB9ANPC1
SCHEMBL24510733 0.81 MMP9 (0.64) CYP3A4CYP2E1CYP2C8CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024019541-A1 HETEROARYL DERIVATIVE COMPOUND AND USE THEREOF 일동제약(주) 2024-01-25 WO disclosed
EP-0266326-B1 NOVEL DERIVATIVES OF BENZIMIDAZOLES ACTIVE AS ANTI-ULCER AGENTS Aktiebolaget Hässle (SE) 1993-03-10 EP disclosed
US-5106862-A DERIVATIVES OF BENZIMIDAZOLES ACTIVE AS ANTI-ULCER AGENTS AKTIEBOLAGET HASSLE (SE) 1992-04-21 US disclosed
EP-0266326-A1 Novel derivatives of benzimidazoles active as anti-ulcer agents Aktiebolaget Hässle (SE) 1988-05-04 EP disclosed