Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | S100A4 | P26447 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31563811 | 0.70 | PDK2 (0.35) | THRBTDP1ALDH1A1KMT2AMEN1 | |
| SCHEMBL22172193 | 0.70 | PDK2 (0.34) | TDP1ALDH1A1ITGA4S100A4PDK2 | |
| SCHEMBL7258801 | 0.69 | APOBEC3A (0.48) | TDP1ALDH1A1KMT2AITGA4MEN1 | |
| SCHEMBL29374343 | 0.69 | APOBEC3A (0.48) | TDP1ALDH1A1KMT2AITGA4MEN1 | |
| SCHEMBL30888607 | 0.68 | THRB (0.47) | THRBTDP1ALDH1A1APEX1KMT2A | |
| SCHEMBL9938667 | 0.68 | THRB (0.47) | THRBTDP1ALDH1A1APEX1KMT2A | |
| SCHEMBL23292666 | 0.66 | KDM4E (0.38) | TDP1ALDH1A1KMT2AITGA4MEN1 | |
| SCHEMBL29840752 | 0.66 | KDM4E (0.38) | TDP1ALDH1A1KMT2AITGA4MEN1 | |
| SCHEMBL11294332 | 0.66 | S100A4 (0.33) | THRBTDP1ALDH1A1KMT2AITGA4 | |
| SCHEMBL4636505 | 0.66 | THRB (0.48) | THRBTDP1ALDH1A1APEX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0289170-B1 | AZABICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1993-06-23 | — | — | EP | disclosed |
| US-4882327-A | NERVOUS SYSTEM DISORDERS | BEECHAM GROUP P.L.C. (GB) | 1989-11-21 | — | — | US | disclosed |
| EP-0289170-A2 | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-11-02 | — | — | EP | disclosed |