Sugi Predict

Sugi Predict / Compounds / SCHEMBL9938667

SCHEMBL9938667

SCHEMBL9938667

CC1(C(=O)Cl)c2ccccc2-c2ccccc21

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ THRB P10828 1/20 0.47
▸ TDP1 Q9NUW8 1/20 0.47
▸ APEX1 P27695 1/20 0.41
▸ S100A4 P26447 1/20 0.41
▸ ALDH1A1 P00352 3/20 0.40
▸ ITGA4 P13612 2/20 0.40
▸ MAPT P10636 1/20 0.40
▸ KMT2A Q03164 1/20 0.39
▸ PDK2 Q15119 7/20 0.39
▸ HSP90AA1 P07900 1/20 0.36
▸ HSP90AB1 P08238 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30888607 1.00 THRB (0.47) THRBTDP1APEX1S100A4ALDH1A1
SCHEMBL393095 0.80 THRB (0.59) THRBTDP1APEX1S100A4ALDH1A1
SCHEMBL4636505 0.80 THRB (0.48) THRBTDP1APEX1S100A4ALDH1A1
Bromide SCHEMBL27743787 0.78 THRB (0.57) THRBTDP1APEX1S100A4ALDH1A1
Bromomethane SCHEMBL209152 0.77 THRB (0.55) THRBTDP1APEX1S100A4ALDH1A1
SCHEMBL25059105 0.75 PDK2 (0.33) THRBTDP1ALDH1A1PDK2
SCHEMBL4217613 0.75 ALDH1A1 (0.49) THRBTDP1APEX1ALDH1A1ITGA4
SCHEMBL22047814 0.73 KMT2A (0.31) KMT2A
SCHEMBL13539402 0.71 ALDH1A1 (0.47) ALDH1A1MAPTKMT2APDK2
SCHEMBL18493492 0.71 THRB (0.48) THRBTDP1APEX1ALDH1A1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118027047-A Preparation method of sandy midbody 西安交通大学 2024-05-14 — — CN claimed
WO-2024121129-A1 COMPOUNDS FOR THE TREATMENT OF NEUROMUSCULAR DISORDERS NMD PHARMA A/S (DK) 2024-06-13 — — WO disclosed
CN-118027047-A Preparation method of sandy midbody 西安交通大学 2024-05-14 — — CN disclosed
CN-117756950-A Bio-based carbonylation reagent and application thereof 东北林业大学 2024-03-26 — — CN disclosed
US-11834460-B2 Imide-based modulators of proteolysis and associated methods of use YALE UNIVERSITY (US) 2023-12-05 — — US disclosed
US-11834460-B2 Imide-based modulators of proteolysis and associated methods of use YALE UNIVERSITY (US) 2023-12-05 — — US disclosed
US-20230331681-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2023-10-19 — — US disclosed
US-20230331681-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2023-10-19 — — US disclosed
US-11591225-B2 Method for producing carbon monoxide COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) 2023-02-28 — — US disclosed
EP-3660004-B1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS INC (US) 2023-02-22 — — EP disclosed
WO-2019141634-A1 METHOD FOR PRODUCING CARBON MONOXIDE COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) 2019-07-25 — — WO disclosed
WO-2018071606-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR Arvinas, Inc. (US) 2018-04-19 — — WO disclosed
US-20180099940-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR ARVINAS OPERATIONS, INC. 2018-04-12 — — US disclosed
US-20160058872-A1 IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2016-03-03 — — US disclosed
US-20160058872-A1 IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2016-03-03 — — US disclosed
WO-2015160845-A2 IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE Arvinas, Inc. (US) 2015-10-22 — — WO disclosed
US-20150291562-A1 IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2015-10-15 — — US disclosed
US-20150291562-A1 IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. 2015-10-15 — — US disclosed
WO-2012079583-A1 SYSTEM PROVIDING CONTROLLED DELIVERY OF GASEOUS CO FOR CARBONYLATION REACTIONS AARHUS UNIVERSITET (DK) 2012-06-21 — — WO disclosed
WO-2012079583-A1 SYSTEM PROVIDING CONTROLLED DELIVERY OF GASEOUS CO FOR CARBONYLATION REACTIONS AARHUS UNIVERSITET (DK) 2012-06-21 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11591225-B2 Method for producing carbon monoxide ALDOA, CYP4A11, ADH1A THRB 3452/4885TDP1 4319/4885APEX1 2583/4885
US-20160058872-A1 IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE CRBN, MDM2, UBE2N THRB 3139/4885TDP1 1896/4885APEX1 1812/4885
US-20230331681-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AR, ADRM1, CRBN THRB 654/4885TDP1 2798/4885APEX1 1326/4885
US-20180099940-A1 COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR AR, ADRM1, CRBN THRB 658/4885TDP1 2820/4885APEX1 1359/4885
US-20150291562-A1 IMIDE-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE CRBN, MDM2, UBE2N THRB 3139/4885TDP1 1896/4885APEX1 1812/4885
US-11834460-B2 Imide-based modulators of proteolysis and associated methods of use CRBN, MDM2, UBE2N THRB 3139/4885TDP1 1896/4885APEX1 1812/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.