Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB4 known ✓ | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 known ✓ | P32297 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.35 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL209065 | 0.88 | ALDH1A1 (0.67) | ALDH1A1TSHRHSD17B10LMNACHRM5 | |
| 2-Ethoxyethanol SCHEMBL327080 | 0.87 | ALDH1A1 (0.67) | ALDH1A1TSHRHSD17B10LMNACHRM5 | |
| Ether SCHEMBL4554714 | 0.86 | ALDH1A1 (0.59) | ALDH1A1TSHRHSD17B10LMNACHRM5 | |
| Ether SCHEMBL9639111 | 0.86 | ALDH1A1 (0.71) | ALDH1A1TSHRHSD17B10LMNACHRM5 | |
| Ether SCHEMBL9839409 | 0.86 | ALDH1A1 (0.64) | ALDH1A1TSHRHSD17B10LMNACHRM5 | |
| Ether SCHEMBL5169727 | 0.84 | ALDH1A1 (0.48) | ALDH1A1TSHRHSD17B10LMNATHRB | |
| Alcohol SCHEMBL5169729 | 0.84 | ALDH1A1 (0.50) | ALDH1A1TSHRHSD17B10LMNACHRM5 | |
| SCHEMBL6933115 | 0.84 | ALDH1A1 (0.54) | ALDH1A1TSHRHSD17B10LMNACHRM5 | |
| 2-Ethoxyethanol SCHEMBL9061826 | 0.84 | ALDH1A1 (0.62) | ALDH1A1TSHRHSD17B10LMNACHRM5 | |
| Diethylene Glycol Monoethyl Ether SCHEMBL29037448 | 0.84 | ALDH1A1 (0.68) | ALDH1A1TSHRHSD17B10LMNACHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222396-B1 | METHOD FOR PRODUCING BEADS | DPX HOLDINGS BV (NL) | 2017-03-01 | — | — | EP | disclosed |
| US-9511336-B2 | System and method for producing beads | DPX HOLDINGS B.V. (NL) | 2016-12-06 | — | — | US | disclosed |
| EP-2289618-B1 | Separation method using asymmetric porous adsorptive beads | EMD MILLIPORE CORP (US) | 2016-08-24 | — | — | EP | disclosed |
| EP-3037166-A1 | ASYMMETRIC POROUS ADSORPTIVE BEAD | EMD Millipore Corporation (US) | 2016-06-29 | — | — | EP | disclosed |
| EP-1764151-B1 | Method and apparatus for making porous agarose beads | UPFRONT CHROMATOGRAPHY AS (DK) | 2016-04-13 | — | — | EP | disclosed |
| US-9295928-B2 | Porous adsorptive or chromatographic media | EMD MILLIPORE CORPORATION (US) | 2016-03-29 | — | — | US | disclosed |
| US-20160038898-A1 | SYSTEM AND METHOD FOR PRODUCING BEADS | DPX HOLDINGS B.V. (NL) | 2016-02-11 | — | — | US | disclosed |
| US-9192907-B2 | System and method for producing beads | DPX HOLDINGS B.V. (NL) | 2015-11-24 | — | — | US | disclosed |
| EP-1764152-B1 | Asymmetric porous adsorptive bead | EMD MILLIPORE CORP (US) | 2015-11-11 | — | — | EP | disclosed |
| US-9067976-B2 | Asymmetric porous adsorptive bead | EMD MILLIPORE CORPORATION (US) | 2015-06-30 | — | — | US | disclosed |
| US-20050220982-A1 | Method of forming polysaccharide structures | MILLIPORE CORPORATION (US) | 2005-10-06 | — | — | US | disclosed |
| US-20050211615-A1 | Porous adsorptive or chromatographic media | MILLIPORE CORPORATION (US) | 2005-09-29 | — | — | US | disclosed |
| US-20050211616-A1 | Porous adsorptive or chromatographic media | MILLIPORE CORPORATION (US) | 2005-09-29 | — | — | US | disclosed |
| US-20050191426-A1 | mixing water soluble polymers, solvents, porogens and curing agents to form a mixtures, then applying the mixture onto porous substrates, drying, curing the coating and rinsing the substrate to remove residues; porometric materials that allow convective or diffusive fluid flow; chromatography; adsorbents | EMD MILLIPORE CORPORATION | 2005-09-01 | — | — | US | disclosed |
| US-20050192249-A1 | Room temperature stable agarose solutions | EMD MILLIPORE CORPORATION | 2005-09-01 | — | — | US | disclosed |
| WO-2005078016-A1 | ROOM TEMPERATURE STABLE AGAROSE SOLUTIONS | MILLIPORE CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |
| WO-2005077528-A1 | POROUS ADSORPTIVE OR CHROMATOGRAPHIC MEDIA | MILLIPORE CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |
| WO-2005077529-A1 | POROUS ADSORPTIVE OR CHROMATOGRAPHIC MEDIA | MILLIPORE CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |
| WO-2005077500-A1 | METHOD OF FORMING COATED STRUCTURES | MILLIPORE CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |
| WO-2005078028-A1 | METHOD OF FORMING POLYSACCHARIDE STRUCTURES | MILLIPORE CORPORATION (US) | 2005-08-25 | — | — | WO | disclosed |