Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 9/20 | 0.69 |
| ▸ | HTR1A | P08908 | 8/20 | 0.69 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.69 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 3/20 | 0.59 |
| ▸ | DRD3 | P35462 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527073 | 0.97 | HTR1A (0.65) | ADRA1AHTR1AADRA1DADRA1BCYP3A4 | |
| SCHEMBL9527049 | 0.96 | HTR1A (0.64) | ADRA1AHTR1AADRA1DADRA1BCYP3A4 | |
| SCHEMBL9528533 | 0.94 | ADRA1A (0.71) | ADRA1AHTR1AADRA1DADRA1BCYP3A4 | |
| SCHEMBL9527503 | 0.86 | ADRA1A (0.57) | ADRA1AHTR1AADRA1DADRA1BCYP3A4 | |
| SCHEMBL9529034 | 0.85 | ADRA1A (0.56) | ADRA1AHTR1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527001 | 0.85 | ADRA1A (0.63) | ADRA1AHTR1AADRA1DADRA1BCYP3A4 | |
| SCHEMBL9527664 | 0.84 | HTR1A (0.58) | ADRA1AHTR1AADRA1DADRA1BDRD2 | |
| SCHEMBL9528402 | 0.84 | HTR1A (0.61) | ADRA1AHTR1AADRA1DADRA1BCYP3A4 | |
| SCHEMBL9528063 | 0.83 | ADRA1A (0.77) | ADRA1AHTR1AADRA1DADRA1BCYP3A4 | |
| SCHEMBL9527827 | 0.82 | HTR1A (0.60) | ADRA1AHTR1AADRA1DADRA1BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |