Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.65 |
| ▸ | ADRA1A | P35348 | 9/20 | 0.65 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.65 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.65 |
| ▸ | DRD2 | P14416 | 8/20 | 0.64 |
| ▸ | DRD3 | P35462 | 5/20 | 0.64 |
| ▸ | HTR7 | P34969 | 4/20 | 0.61 |
| ▸ | HTR2A | P28223 | 4/20 | 0.61 |
| ▸ | HTR6 | P50406 | 3/20 | 0.61 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.58 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527049 | 0.99 | HTR1A (0.64) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9531299 | 0.97 | ADRA1A (0.69) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9528533 | 0.93 | ADRA1A (0.71) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527827 | 0.85 | HTR1A (0.60) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9528918 | 0.85 | HTR1A (0.59) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527740 | 0.84 | DRD2 (0.64) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527503 | 0.83 | ADRA1A (0.57) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527664 | 0.83 | HTR1A (0.58) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9529034 | 0.82 | ADRA1A (0.56) | HTR1AADRA1AADRA1DADRA1BDRD2 | |
| SCHEMBL9527001 | 0.82 | ADRA1A (0.63) | HTR1AADRA1AADRA1DADRA1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |