Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.40 |
| ▸ | PDCD1 | Q15116 | 6/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | XPO1 | O14980 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535163 | 0.81 | MAOB (0.47) | MAOBCD274PDCD1BRD4 | |
| SCHEMBL9532880 | 0.79 | MAOB (0.50) | MAOBCD274PDCD1BRD4 | |
| SCHEMBL9534350 | 0.77 | MAPT (0.59) | MAOBCD274PDCD1SMN1; SMN2KDM4E | |
| SCHEMBL9536506 | 0.75 | CD274 (0.54) | MAOBCD274PDCD1BRD4SMN1; SMN2 | |
| SCHEMBL9532759 | 0.74 | MAOB (0.59) | MAOBCD274PDCD1KMT2AKDM4E | |
| SCHEMBL9534473 | 0.72 | CD274 (0.59) | MAOBCD274PDCD1KMT2AMAPT | |
| SCHEMBL9533962 | 0.72 | MAOB (0.62) | MAOBCD274PDCD1NPC1RAB9A | |
| SCHEMBL9538966 | 0.72 | MEN1 (0.48) | MAOBCD274PDCD1KMT2AKDM4E | |
| SCHEMBL10382659 | 0.71 | MAOB (0.64) | MAOBSMN1; SMN2TSHRKMT2AKDM4E | |
| SCHEMBL9536771 | 0.71 | MAOB (0.61) | MAOBCD274PDCD1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0539372-A1 | THERAPEUTIC AGENTS | The Boots Company PLC (GB) | 1993-05-05 | — | — | EP | disclosed |
| WO-1991011448-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1991-08-08 | — | — | WO | disclosed |