Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 8/20 | 0.61 |
| ▸ | AGTR2 | P50052 | 8/20 | 0.61 |
| ▸ | CNR2 | P34972 | 5/20 | 0.51 |
| ▸ | CNR1 | P21554 | 3/20 | 0.51 |
| ▸ | RHEB | Q15382 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9422897 | 0.84 | AGTR1 (0.86) | AGTR1AGTR2PPARG | |
| SCHEMBL9200811 | 0.76 | AGTR1 (1.00) | AGTR1AGTR2RHEBPPARG | |
| SCHEMBL9531834 | 0.76 | ALOX5AP (0.50) | AGTR1AGTR2CNR2CNR1JAK2 | |
| SCHEMBL6168981 | 0.72 | AGTR1 (0.57) | AGTR1AGTR2PPARG | |
| SCHEMBL9125532 | 0.70 | AGTR1 (0.80) | AGTR1AGTR2PPARG | |
| SCHEMBL7671655 | 0.69 | AGTR1 (0.83) | AGTR1AGTR2PPARG | |
| SCHEMBL9124594 | 0.69 | AGTR1 (0.78) | AGTR1AGTR2PPARG | |
| SCHEMBL9422812 | 0.68 | AGTR1 (0.58) | AGTR1AGTR2 | |
| SCHEMBL7055933 | 0.67 | AGTR2 (0.66) | AGTR1AGTR2 | |
| SCHEMBL10430040 | 0.67 | AGTR1 (0.80) | AGTR1AGTR2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525129-A4 | SUBSTITUTED BENZIMIDAZOLES | — | 1993-03-24 | — | — | EP | claimed |
| EP-0525129-A1 | SUBSTITUTED BENZIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1993-02-03 | — | — | EP | claimed |
| WO-1991016313-A1 | SUBSTITUTED BENZIMIDAZOLES | SMITHKLINE BEECHAM CORPORATION (US) | 1991-10-31 | — | — | WO | claimed |