Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 2/20 | 0.41 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.41 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.41 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.34 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529816 | 0.86 | ABCC9 (0.41) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9530459 | 0.83 | ABCC9 (0.51) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9532374 | 0.81 | ABCC9 (0.44) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9530832 | 0.77 | ABCC9 (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9530830 | 0.77 | ABCC9 (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9531246 | 0.77 | ABCC9 (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9531501 | 0.72 | LMNA (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL10538984 | 0.72 | LMNA (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9529808 | 0.72 | LMNA (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9531495 | 0.72 | LMNA (0.43) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214743-B1 | USE OF QUINOLINE DERIVATIVES IN THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF CEREBROVASCULAR DISORDERS AND CEREBRAL SENILITY | BEECHAM GROUP PLC (GB) | 1993-05-12 | — | — | EP | claimed |
| EP-0150202-B1 | DI/TETRA-HYDROQUINOLINES | BEECHAM GROUP PLC (GB) | 1988-07-06 | — | — | EP | claimed |