Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 4/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.48 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1796749 | 0.90 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL8289135 | 0.90 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL1796753 | 0.90 | NPC1 (0.53) | NPC1RAB9ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL9530015 | 0.87 | KDM4E (0.57) | NPC1RAB9ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL9532773 | 0.83 | SMN1; SMN2 (0.57) | NPC1RAB9ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL10406690 | 0.82 | ALDH1A1 (0.59) | NPC1RAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL13606804 | 0.82 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2LMNAPKM | |
| SCHEMBL9532752 | 0.82 | RAB9A (0.47) | NPC1RAB9ASMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL9529568 | 0.81 | KDM4E (0.51) | NPC1RAB9APKMCDK5CDK5R1 | |
| SCHEMBL9530136 | 0.79 | ALDH1A1 (0.62) | NPC1RAB9ASMN1; SMN2LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0366006-B1 | PYRIDYLKETOXIME ETHER COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING IT | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1993-09-29 | — | — | EP | disclosed |
| US-4971985-A | ANTIISCHEMIC AGENTS, CARDIOVASCULAR DISORDERS | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1990-11-20 | — | — | US | disclosed |