Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 8/20 | 0.64 |
| ▸ | PDE3A | Q14432 | 8/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 5/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | GFER | P55789 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9528352 | 0.91 | PDE3B (0.68) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9529826 | 0.84 | PDE3B (0.70) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9038679 | 0.83 | PDE3B (0.70) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9528728 | 0.81 | PDE3B (0.95) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL8552796 | 0.79 | PDE3B (0.88) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL8555995 | 0.79 | PDE3B (0.88) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL6792537 | 0.78 | PDE3B (0.67) | PDE3BPDE3AKCNH2MAPTTSHR | |
| SCHEMBL9039084 | 0.78 | PDE3B (0.61) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL9038866 | 0.78 | PDE3B (0.84) | PDE3BPDE3AKCNH2PDE4APDE4B | |
| SCHEMBL4322811 | 0.78 | PDE3B (1.00) | PDE3BPDE3AKCNH2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294647-B1 | THIADIAZINONES | MERCK PATENT GmbH (DE) | 1993-07-21 | — | — | EP | disclosed |
| US-4916128-A | Thiadiazinones | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1990-04-10 | — | — | US | disclosed |
| EP-0294647-A2 | Thiadiazinones | MERCK PATENT GmbH (DE) | 1988-12-14 | — | — | EP | disclosed |