Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 1/20 | 0.40 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CCKBR | P32239 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592121 | 0.93 | PLA2G10 (0.39) | PLA2G10PLA2G5ALDH1A1KDM4EHPGD | |
| SCHEMBL22882469 | 0.85 | PLA2G10 (0.35) | PLA2G10PLA2G5ALDH1A1KDM4EPOLB | |
| SCHEMBL4955615 | 0.82 | ALDH1A1 (0.36) | ALDH1A1HPGDTSHRMEN1KMT2A | |
| SCHEMBL18132880 | 0.80 | PLA2G10 (0.37) | PLA2G10PLA2G5ALDH1A1KDM4EHPGD | |
| SCHEMBL2754581 | 0.78 | ALDH1A1 (0.49) | ALDH1A1KDM4EHPGDTSHRPOLB | |
| SCHEMBL4477991 | 0.78 | ATAD2 (0.45) | CCKBR | |
| SCHEMBL10465762 | 0.78 | NPSR1 (0.49) | ALDH1A1HPGDTSHRPOLBSMN1; SMN2 | |
| SCHEMBL24774078 | 0.77 | ALDH1A1 (0.41) | PLA2G10PLA2G5ALDH1A1KDM4EPOLB | |
| SCHEMBL14789789 | 0.77 | GSK3A (0.59) | PLA2G10PLA2G5ALDH1A1KDM4EHPGD | |
| SCHEMBL23320864 | 0.77 | MAPT (0.44) | ALDH1A1CCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0252744-B1 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | LILLY CO ELI (US) | 1993-12-15 | — | — | EP | disclosed |
| US-4734498-A | 3β-succinimidoazetidinones as chiral intermediates | ELI LILLY AND COMPANY (US) | 1988-03-29 | — | — | US | disclosed |
| EP-0252744-A2 | 3-Beta-(3,4-disubstituted succinimido)azetidinones | ELI LILLY AND COMPANY (US) | 1988-01-13 | — | — | EP | disclosed |