SCHEMBL9532537

SCHEMBL9532537

C=CC(O)C(c1ccc(F)cc1)n1cncn1

nearest known ligand 0.47

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 18/20 0.47
HSP90AA1 P07900 1/20 0.41
FAAH O00519 1/20 0.37
MGLL Q99685 1/20 0.37
CYP3A4 P08684 1/20 0.36
CYP11B1 P15538 1/20 0.36
TSHR P16473 1/20 0.36
CYP11B2 P19099 1/20 0.36
CYP2C19 P33261 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9735419 0.74 CYP19A1 (0.47) CYP19A1FAAHMGLLCYP3A4CYP11B1
SCHEMBL9368105 0.73 CYP19A1 (0.68) CYP19A1CYP3A4CYP11B1TSHRCYP11B2
SCHEMBL10709465 0.73 CYP19A1 (0.51) CYP19A1FAAHMGLLCYP3A4CYP11B1
SCHEMBL8769060 0.71 CYP19A1 (0.44) CYP19A1HSP90AA1FAAHMGLLCYP3A4
SCHEMBL11038306 0.70 CYP19A1 (0.45) CYP19A1
SCHEMBL6016102 0.70 CYP19A1 (0.49) CYP19A1
SCHEMBL10467246 0.70 CYP19A1 (0.40) CYP19A1FAAHMGLLCYP3A4CYP11B1
Finrozole SCHEMBL1658815 0.69 CYP19A1 (0.62) CYP19A1CYP3A4CYP11B1TSHRCYP11B2
Finrozole SCHEMBL1649445 0.69 CYP19A1 (0.62) CYP19A1CYP3A4CYP11B1TSHRCYP11B2
Finrozole SCHEMBL2138489 0.69 CYP19A1 (0.62) CYP19A1CYP3A4CYP11B1TSHRCYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0251086-B1 ANTIFUNGAL CARBINOLS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1993-03-17 EP disclosed
US-5084465-A Plant fungicides for agriculture DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1992-01-28 US disclosed
EP-0440608-A1 ANTIFUNGAL CARBINOLS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1991-08-14 EP disclosed
US-4980367-A CONTROLLING PLANT DISEASES E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-12-25 US disclosed
EP-0390850-A4 ANTIFUNGAL CARBINOLS 1990-12-05 EP disclosed
EP-0390850-A1 ANTIFUNGAL CARBINOLS THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1990-10-10 EP disclosed
US-4952232-A Antifungal carbinols E. I. DU PONT DE NEMOURS AND COMPANY (US) 1990-08-28 US disclosed
WO-1989005801-A1 ANTIFUNGAL CARBINOLS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-06-29 WO disclosed
WO-1989005581-A1 ANTIFUNGAL CARBINOLS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-06-29 WO disclosed
EP-0321211-A1 Antifungal carbinols E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-06-21 EP disclosed