Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531601 | 0.87 | MAPK8 (0.43) | — | |
| SCHEMBL9531373 | 0.87 | EGLN1 (0.41) | SRC | |
| SCHEMBL9532793 | 0.86 | KDM4E (0.39) | KDM4ERCE1 | |
| SCHEMBL7435772 | 0.83 | BCL2 (0.41) | — | |
| SCHEMBL9690851 | 0.80 | PPARG (0.44) | KDM4ERCE1GAA | |
| Bromide SCHEMBL9350589 | 0.75 | CYP3A4 (0.41) | — | |
| SCHEMBL9530986 | 0.73 | AGTR1 (0.40) | KDM4EALDH1A1RECQLL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7284739 | 0.72 | AGTR1 (0.41) | — | |
| SCHEMBL7322677 | 0.72 | MAPT (0.39) | MEN1ALDH1A1RECQLKMT2A | |
| SCHEMBL9262511 | 0.72 | ALDH1A1 (0.39) | ALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | claimed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | claimed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |