Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533159 | 0.83 | KDM4E (0.39) | — | |
| SCHEMBL9531601 | 0.81 | MAPK8 (0.43) | — | |
| SCHEMBL9531373 | 0.80 | EGLN1 (0.41) | — | |
| SCHEMBL9532793 | 0.80 | KDM4E (0.39) | — | |
| SCHEMBL9531997 | 0.80 | PPARG (0.45) | BCL2MCL1 | |
| SCHEMBL9402002 | 0.78 | ALDH1A1 (0.49) | AGTR1 | |
| SCHEMBL7322677 | 0.76 | MAPT (0.39) | AGTR1 | |
| SCHEMBL684181 | 0.76 | AGTR1 (0.50) | AGTR1 | |
| SCHEMBL9262511 | 0.76 | ALDH1A1 (0.39) | — | |
| SCHEMBL8258996 | 0.75 | AGTR1 (0.56) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | claimed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | claimed |
| EP-0618207-B1 | Substituted pyridopyrimidines as antihypertensives | AMERICAN HOME PROD (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0863143-A1 | Intermediates useful in the production of pyridopyrimidone angiotensin AII antagonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0500297-A1 | Substituted pyridinones and pyrimidinones as angiotensin II antagonists | FISONS plc (GB) | 1992-08-26 | — | — | EP | disclosed |