Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 16/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.40 |
| ▸ | GAA | P10253 | 12/20 | 0.40 |
| ▸ | HPGD | P15428 | 10/20 | 0.40 |
| ▸ | GLA | P06280 | 6/20 | 0.40 |
| ▸ | CASP1 | P29466 | 5/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532298 | 0.88 | ALDH1A1 (0.45) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL10640498 | 0.87 | KDM4E (0.39) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL9630958 | 0.84 | KDM4E (0.37) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL9531337 | 0.83 | KDM4E (0.40) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL9530822 | 0.78 | KDM4E (0.35) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL9531822 | 0.77 | MAOB (0.43) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL9531668 | 0.77 | KDM4E (0.44) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL9632113 | 0.75 | CYP1A1 (0.35) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL9632290 | 0.75 | ALDH1A1 (0.44) | KDM4EALDH1A1GAAHPGDGLA | |
| SCHEMBL10639179 | 0.75 | KDM4E (0.41) | KDM4EALDH1A1GAAHPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277836-B1 | THIAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE | Sankyo Company Limited (JP) | 1993-06-02 | — | — | EP | disclosed |
| US-4873255-A | REDUCE BLOOD GLUCOSE AND BLOOD LIPID LEVELS | SANKYO COMPANY LIMITED (JP) | 1989-10-10 | — | — | US | disclosed |
| EP-0277836-A1 | Thiazolidinone derivatives, their preparation and their use | Sankyo Company Limited (JP) | 1988-08-10 | — | — | EP | disclosed |