Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | PTGES | O14684 | 3/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535514 | 0.90 | ALOX5 (0.46) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL9534066 | 0.87 | ALOX5 (0.54) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL9536280 | 0.79 | ALOX5 (0.48) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL9458555 | 0.77 | ALOX5 (0.52) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL9458503 | 0.75 | ALOX5 (0.70) | ALOX5PTGS1PTGES | |
| SCHEMBL9531975 | 0.72 | PTGES (0.80) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL13844797 | 0.69 | PTGES (0.61) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL3984072 | 0.69 | PTGES (0.77) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL1879669 | 0.68 | CYP2C9 (0.60) | PTGS2 | |
| SCHEMBL1879667 | 0.68 | CYP2C9 (0.60) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | disclosed |
| EP-0397175-B1 | Substituted pyrrolizine compounds and theit use as pharmaceuticals | DANNHARDT GERD PROF DR (DE) | 1993-12-08 | — | — | EP | disclosed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | disclosed |