Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.46 |
| ▸ | PTGES | O14684 | 3/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533396 | 0.90 | ALOX5 (0.46) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL9458555 | 0.88 | ALOX5 (0.52) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL9458967 | 0.81 | ALOX5 (0.47) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL9535920 | 0.79 | ALOX5 (0.47) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL9534066 | 0.76 | ALOX5 (0.54) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL9458503 | 0.74 | ALOX5 (0.70) | ALOX5PTGS1PTGESALDH1A1 | |
| SCHEMBL9458529 | 0.74 | PTGES (0.77) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL9458628 | 0.73 | ALOX5 (0.48) | ALOX5PTGS1PTGESALOX5APPTGS2 | |
| SCHEMBL4655748 | 0.69 | CA12 (0.65) | PTGS2ALDH1A1LMNAMAPTTHRB | |
| SCHEMBL4655750 | 0.69 | CA12 (0.65) | PTGS2ALDH1A1LMNAMAPTTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397175-B1 | Substituted pyrrolizine compounds and theit use as pharmaceuticals | DANNHARDT GERD PROF DR (DE) | 1993-12-08 | — | — | EP | disclosed |
| EP-0397175-A1 | Substituted pyrrolizine compounds and theit use as pharmaceuticals | Dannhardt, Gerd, Prof.Dr. (DE) | 1990-11-14 | — | — | EP | disclosed |