Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HTR3A | P46098 | 5/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.46 |
| ▸ | HTR3B | O95264 | 3/20 | 0.46 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.46 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.46 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531070 | 0.86 | HPGD (0.37) | MEN1KMT2AALDH1A1CYP3A4TSHR | |
| SCHEMBL1559634 | 0.74 | MEN1 (0.74) | MEN1KMT2AALDH1A1CYP3A4TSHR | |
| SCHEMBL9531125 | 0.73 | CHRM2 (0.59) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL9533193 | 0.72 | CHRM2 (0.58) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9532593 | 0.72 | GAA (0.59) | MEN1KMT2AALDH1A1CYP3A4TSHR | |
| SCHEMBL9533289 | 0.71 | HTR3A (0.55) | MEN1KMT2AALDH1A1CYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL9533542 | 0.70 | HTR3A (0.54) | MEN1KMT2AALDH1A1CYP3A4TSHR | |
| SCHEMBL3533984 | 0.69 | GAA (0.68) | MEN1KMT2AALDH1A1CYP3A4TSHR | |
| Ricasetron SCHEMBL21715163 | 0.69 | NOTUM (0.52) | HTR3A | |
| Ricasetron SCHEMBL634827 | 0.69 | NOTUM (0.52) | HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0289170-B1 | AZABICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1993-06-23 | — | — | EP | claimed |
| EP-0289170-A2 | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-11-02 | — | — | EP | claimed |