Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HTR3A | P46098 | 6/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.54 |
| ▸ | HTR3B | O95264 | 3/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.54 |
| ▸ | CCR3 | P51677 | 3/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533289 | 0.81 | HTR3A (0.55) | MEN1KMT2AALDH1A1HTR3AHTR3E | |
| Hydrochloric Acid SCHEMBL9533542 | 0.80 | HTR3A (0.54) | MEN1KMT2AALDH1A1HTR3AHTR3E | |
| SCHEMBL1559634 | 0.79 | MEN1 (0.74) | MEN1KMT2AALDH1A1LMNANPSR1 | |
| SCHEMBL3533984 | 0.77 | GAA (0.68) | GAAMEN1KMT2AALDH1A1HTR3A | |
| SCHEMBL9747490 | 0.77 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1HTR3AHTR3E | |
| SCHEMBL2084615 | 0.75 | HTR3A (0.55) | MEN1KMT2AALDH1A1HTR3AHTR3E | |
| SCHEMBL7435024 | 0.74 | NPC1 (0.63) | GAASMN1; SMN2HTR3AHTR3EHTR3B | |
| SCHEMBL9531967 | 0.73 | HTR3A (0.57) | MEN1KMT2AALDH1A1HTR3AHTR3E | |
| SCHEMBL7939878 | 0.73 | HTR3A (0.86) | HTR3ACYP3A4 | |
| SCHEMBL2459495 | 0.73 | LMNA (0.52) | KMT2AALDH1A1LMNAHTR3AHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0289170-B1 | AZABICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1993-06-23 | — | — | EP | claimed |
| EP-0289170-A2 | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-11-02 | — | — | EP | claimed |
| EP-0289170-B1 | AZABICYCLIC COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1993-06-23 | — | — | EP | disclosed |
| US-4882327-A | NERVOUS SYSTEM DISORDERS | BEECHAM GROUP P.L.C. (GB) | 1989-11-21 | — | — | US | disclosed |
| EP-0289170-A2 | Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1988-11-02 | — | — | EP | disclosed |