Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 8/20 | 0.70 |
| ▸ | MAPT | P10636 | 7/20 | 0.70 |
| ▸ | BACE1 | P56817 | 4/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.64 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.64 |
| ▸ | STAT3 | P40763 | 3/20 | 0.64 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.64 |
| ▸ | RELA | Q04206 | 3/20 | 0.64 |
| ▸ | MMP9 | P14780 | 3/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.64 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.64 |
| ▸ | MAOA | P21397 | 2/20 | 0.64 |
| ▸ | MAOB | P27338 | 2/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533579 | 1.00 | APP (0.70) | APPMAPTBACE1ALOX5NFKB1 | |
| SCHEMBL9535664 | 0.89 | ALOX5 (0.67) | APPMAPTBACE1ALOX5NFKB1 | |
| SCHEMBL10538423 | 0.89 | ALOX5 (0.67) | APPMAPTBACE1ALOX5NFKB1 | |
| SCHEMBL9533984 | 0.85 | CAPN1 (0.55) | APPMAPTBACE1ALOX5NFKB1 | |
| SCHEMBL9533980 | 0.85 | CAPN1 (0.55) | APPMAPTBACE1ALOX5NFKB1 | |
| SCHEMBL9579738 | 0.84 | ALOX5 (0.57) | APPMAPTBACE1ALOX5NFKB1 | |
| SCHEMBL9579740 | 0.84 | ALOX5 (0.57) | APPMAPTBACE1ALOX5NFKB1 | |
| SCHEMBL9579827 | 0.84 | ALOX5 (0.57) | APPMAPTBACE1ALOX5NFKB1 | |
| SCHEMBL3220811 | 0.82 | APP (1.00) | APPMAPTBACE1ALOX5NFKB1 | |
| SCHEMBL3220795 | 0.82 | APP (1.00) | APPMAPTBACE1ALOX5NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4810716-A | ANTIINFLAMMATORY, ANTIALLERGY, ANTIISCHEMIC | WARNER-LAMBERT COMPANY (US) | 1989-03-07 | — | — | US | claimed |
| EP-0241043-A2 | Novel diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1987-10-14 | — | — | EP | claimed |
| EP-0241043-B1 | NOVEL DIARYLALKANOIDS HAVING ACTIVITY AS LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-09-01 | — | — | EP | disclosed |
| US-5177259-A | Diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1993-01-05 | — | — | US | disclosed |
| US-5142095-A | Treating inflammation, allergies, asthma, cardiovascular disorders, psoriasis | WARNER-LAMBERT COMPANY (US) | 1992-08-25 | — | — | US | disclosed |
| US-5077411-A | Antiallergens, antiinflammatory agents; cardiovascular disorders, migraines, psoriasis | WARNER-LAMBERT CO. (US) | 1991-12-31 | — | — | US | disclosed |
| US-4959503-A | Diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1990-09-25 | — | — | US | disclosed |
| US-4810716-A | ANTIINFLAMMATORY, ANTIALLERGY, ANTIISCHEMIC | WARNER-LAMBERT COMPANY (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0241043-A2 | Novel diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1987-10-14 | — | — | EP | disclosed |