Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | POLB | P06746 | 4/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | APP | P05067 | 4/20 | 0.51 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | PTGES | O14684 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 2/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9579738 | 1.00 | ALOX5 (0.57) | ALOX5KDM4EGAAMAPTPOLB | |
| SCHEMBL9579827 | 1.00 | ALOX5 (0.57) | ALOX5KDM4EGAAMAPTPOLB | |
| SCHEMBL10538423 | 0.92 | ALOX5 (0.67) | ALOX5KDM4EGAAMAPTPOLB | |
| SCHEMBL9535664 | 0.92 | ALOX5 (0.67) | ALOX5KDM4EGAAMAPTPOLB | |
| SCHEMBL9579766 | 0.85 | MAPT (0.51) | ALOX5KDM4EGAAMAPTPOLB | |
| SCHEMBL9579773 | 0.85 | MAPT (0.51) | ALOX5KDM4EGAAMAPTPOLB | |
| SCHEMBL9579769 | 0.85 | MAPT (0.51) | ALOX5KDM4EGAAMAPTPOLB | |
| SCHEMBL9533579 | 0.84 | APP (0.70) | ALOX5KDM4EGAAMAPTPOLB | |
| SCHEMBL9533573 | 0.84 | APP (0.70) | ALOX5KDM4EGAAMAPTPOLB | |
| SCHEMBL10468741 | 0.82 | ALOX5 (0.84) | ALOX5KDM4EGAAMAPTAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5177259-A | Diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1993-01-05 | — | — | US | disclosed |
| US-5142095-A | Treating inflammation, allergies, asthma, cardiovascular disorders, psoriasis | WARNER-LAMBERT COMPANY (US) | 1992-08-25 | — | — | US | disclosed |
| US-5077411-A | Antiallergens, antiinflammatory agents; cardiovascular disorders, migraines, psoriasis | WARNER-LAMBERT CO. (US) | 1991-12-31 | — | — | US | disclosed |
| US-4959503-A | Diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1990-09-25 | — | — | US | disclosed |