Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.67 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | APP | P05067 | 2/20 | 0.56 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | PTGES | O14684 | 2/20 | 0.50 |
| ▸ | STAT3 | P40763 | 2/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10538423 | 1.00 | ALOX5 (0.67) | ALOX5MAPTAPPTNFRSF1ACYP2D6 | |
| SCHEMBL9579740 | 0.92 | ALOX5 (0.57) | ALOX5MAPTAPPTNFRSF1ACYP2D6 | |
| SCHEMBL9579738 | 0.92 | ALOX5 (0.57) | ALOX5MAPTAPPTNFRSF1ACYP2D6 | |
| SCHEMBL9579827 | 0.92 | ALOX5 (0.57) | ALOX5MAPTAPPTNFRSF1ACYP2D6 | |
| SCHEMBL9533579 | 0.89 | APP (0.70) | ALOX5MAPTAPPCYP2D6CYP2C9 | |
| SCHEMBL9533573 | 0.89 | APP (0.70) | ALOX5MAPTAPPCYP2D6CYP2C9 | |
| SCHEMBL10467072 | 0.80 | ALOX5 (1.00) | ALOX5MAPTAPPCYP2D6CYP2C9 | |
| SCHEMBL10467071 | 0.80 | ALOX5 (1.00) | ALOX5MAPTAPPCYP2D6CYP2C9 | |
| SCHEMBL9579737 | 0.78 | MEN1 (0.45) | ALOX5MAPTTNFRSF1APTGS1KDM4E | |
| SCHEMBL9579773 | 0.77 | MAPT (0.51) | ALOX5MAPTAPPTNFRSF1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4810716-A | ANTIINFLAMMATORY, ANTIALLERGY, ANTIISCHEMIC | WARNER-LAMBERT COMPANY (US) | 1989-03-07 | — | — | US | claimed |
| EP-0241043-A2 | Novel diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1987-10-14 | — | — | EP | claimed |
| EP-0241043-B1 | NOVEL DIARYLALKANOIDS HAVING ACTIVITY AS LIPOXYGENASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-09-01 | — | — | EP | disclosed |
| US-5177259-A | Diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1993-01-05 | — | — | US | disclosed |
| US-5142095-A | Treating inflammation, allergies, asthma, cardiovascular disorders, psoriasis | WARNER-LAMBERT COMPANY (US) | 1992-08-25 | — | — | US | disclosed |
| US-5077411-A | Antiallergens, antiinflammatory agents; cardiovascular disorders, migraines, psoriasis | WARNER-LAMBERT CO. (US) | 1991-12-31 | — | — | US | disclosed |
| US-4959503-A | Diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1990-09-25 | — | — | US | disclosed |
| US-4810716-A | ANTIINFLAMMATORY, ANTIALLERGY, ANTIISCHEMIC | WARNER-LAMBERT COMPANY (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0241043-A2 | Novel diarylalkanoids having activity as lipoxygenase inhibitors | WARNER-LAMBERT COMPANY (US) | 1987-10-14 | — | — | EP | disclosed |