Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.64 |
| ▸ | DRD2 | P14416 | 3/20 | 0.64 |
| ▸ | HTR2A | P28223 | 3/20 | 0.64 |
| ▸ | DRD4 | P21917 | 2/20 | 0.64 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.64 |
| ▸ | HTR2C | P28335 | 1/20 | 0.64 |
| ▸ | HRH1 | P35367 | 1/20 | 0.64 |
| ▸ | DRD3 | P35462 | 1/20 | 0.64 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9532906 | 0.98 | HTR1A (0.62) | HTR1ADRD2HTR2ADRD4ADRA2C | |
| Hydrochloric Acid SCHEMBL9533610 | 0.98 | HTR1A (0.62) | HTR1ADRD2HTR2ADRD4ADRA2C | |
| SCHEMBL17598216 | 0.95 | HTR1A (0.62) | HTR1ADRD2HTR2ADRD4ADRA2C | |
| SCHEMBL2113038 | 0.90 | HTR1A (0.71) | HTR1ADRD2HTR2ADRD4ADRA2C | |
| SCHEMBL16862217 | 0.88 | HTR1A (0.64) | HTR1ADRD2HTR2ADRD4ADRA2C | |
| SCHEMBL10332949 | 0.82 | HRH3 (0.62) | HTR1ADRD2HTR2ADRD4ADRA2C | |
| SCHEMBL26108581 | 0.81 | HTR1A (0.65) | HTR1ADRD2HTR2ADRD4ADRA2C | |
| SCHEMBL26492991 | 0.81 | HTR1A (0.65) | HTR1ADRD2HTR2ADRD4ADRA2C | |
| SCHEMBL9532652 | 0.80 | DRD2 (0.56) | HTR1ADRD2HTR2ADRD4ADRA2C | |
| SCHEMBL9633626 | 0.80 | HTR1A (0.77) | HTR1ADRD2HTR2ADRD4ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0314363-B1 | ANTI-ANXIETY AGENTS | PFIZER INC. (US) | 1993-04-07 | — | — | EP | claimed |
| JP-1157979-A | — | — | None | — | — | JP | disclosed |
| CN-1022246-C | Method of preparation 1-acyl-3-(4-(2-pyrimidyl)-1-piperazyl) propane | PFIZER (US) | 1993-09-29 | — | — | CN | disclosed |
| EP-0314363-B1 | ANTI-ANXIETY AGENTS | PFIZER INC. (US) | 1993-04-07 | — | — | EP | disclosed |
| US-4994455-A | 1-(heterocyclcarbonyl)-3-(4-(2-pyrimidinyl)-1-piperazinyl)-propane | PFIZER INC. (US) | 1991-02-19 | — | — | US | disclosed |
| CN-1042148-A | Antianxiety agent | PFIZER (US) | 1990-05-16 | — | — | CN | disclosed |
| JP-H01157979-A | 1-ACYL-3-(4-(2-PYRIMIDINYL)-1-PIPERAZINYL) PROPANES | PFIZER INC | 1989-06-21 | — | — | JP | disclosed |
| WO-1989003831-A1 | ANTI-ANXIETY AGENTS | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |
| EP-0314363-A2 | Anti-anxiety agents | PFIZER INC. (US) | 1989-05-03 | — | — | EP | disclosed |