Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.56 |
| ▸ | HTR1A | P08908 | 4/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.56 |
| ▸ | HTR2A | P28223 | 3/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.56 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9766044 | 0.86 | SIGMAR1 (0.54) | DRD2HTR1ADRD4HTR2ADRD3 | |
| SCHEMBL10817438 | 0.83 | KDM4E (0.61) | DRD2DRD4DRD3HRH3KDM4E | |
| SCHEMBL8700838 | 0.82 | HRH3 (0.61) | DRD2HTR1ADRD4HTR2ADRD3 | |
| SCHEMBL11861074 | 0.81 | CYP1A2 (0.53) | HRH1 | |
| SCHEMBL9533727 | 0.80 | HTR1A (0.64) | DRD2HTR1ADRD4HTR2ADRD3 | |
| SCHEMBL16862217 | 0.80 | HTR1A (0.64) | DRD2HTR1ADRD4HTR2ADRD3 | |
| SCHEMBL8160104 | 0.80 | HTR1A (0.58) | DRD2HTR1ADRD4HTR2ADRD3 | |
| Hydrochloric Acid SCHEMBL8838070 | 0.80 | HRH3 (0.56) | DRD4HTR2AHTR2CHRH1HRH3 | |
| SCHEMBL9755203 | 0.79 | CASP1 (0.49) | — | |
| Hydrochloric Acid SCHEMBL9532906 | 0.79 | HTR1A (0.62) | DRD2HTR1ADRD4HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0314363-B1 | ANTI-ANXIETY AGENTS | PFIZER INC. (US) | 1993-04-07 | — | — | EP | disclosed |
| US-4994455-A | 1-(heterocyclcarbonyl)-3-(4-(2-pyrimidinyl)-1-piperazinyl)-propane | PFIZER INC. (US) | 1991-02-19 | — | — | US | disclosed |
| WO-1989003831-A1 | ANTI-ANXIETY AGENTS | PFIZER INC. (US) | 1989-05-05 | — | — | WO | disclosed |
| EP-0314363-A2 | Anti-anxiety agents | PFIZER INC. (US) | 1989-05-03 | — | — | EP | disclosed |