Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 2/20 | 0.39 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | APLNR | P35414 | 3/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530672 | 0.85 | PPARG (0.58) | PPARGACHEAGTR1 | |
| SCHEMBL9533790 | 0.83 | MEN1 (0.42) | GPR84AGTR1 | |
| SCHEMBL9414243 | 0.83 | DPP4 (0.45) | PPARGDPP4GRIN1GRIN2BACHE | |
| SCHEMBL9414287 | 0.80 | PPARG (0.44) | PPARGDPP4GRIN1GRIN2B | |
| SCHEMBL9690775 | 0.79 | PPARG (0.66) | PPARGACHEAGTR1 | |
| SCHEMBL9531553 | 0.78 | PPARG (0.45) | PPARGGPR84ACHEAGTR1 | |
| SCHEMBL9414278 | 0.76 | DPP4 (0.46) | PPARGDPP4GRIN1GRIN2B | |
| SCHEMBL9414218 | 0.76 | PPARG (0.51) | PPARGDPP4 | |
| SCHEMBL9414213 | 0.75 | DPP4 (0.48) | PPARGDPP4GRIN1GRIN2B | |
| SCHEMBL9414221 | 0.74 | DPP4 (0.43) | PPARGDPP4GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | disclosed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | disclosed |