Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 12/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533788 | 0.83 | PPARG (0.40) | AGTR1GPR84 | |
| SCHEMBL9531553 | 0.83 | PPARG (0.45) | MEN1KMT2AAGTR1AGTR2GPR84 | |
| SCHEMBL9530672 | 0.82 | PPARG (0.58) | AGTR1AGTR2 | |
| SCHEMBL9535397 | 0.76 | AGTR1 (0.70) | AGTR1AGTR2 | |
| SCHEMBL9531136 | 0.76 | AGTR1 (0.56) | AGTR1AGTR2 | |
| SCHEMBL27569853 | 0.76 | CD274 (0.44) | CD274KDM4EALDH1A1MAPK1 | |
| SCHEMBL9690775 | 0.75 | PPARG (0.66) | AGTR1 | |
| SCHEMBL9532984 | 0.73 | AGTR1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL365486 | 0.72 | CD274 (0.44) | CD274KDM4ETSHRHSD17B10ALDH1A1 | |
| SCHEMBL9531605 | 0.72 | AGTR1 (0.56) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0572455-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | Astra Pharmaceuticals Limited (GB) | 1993-12-08 | — | — | EP | disclosed |
| WO-1992014714-A1 | SUBSTITUTED PYRIDINONES AND PYRIMIDINONES AS ANGIOTENSIN II ANTAGONISTS | FISONS PLC (GB) | 1992-09-03 | — | — | WO | disclosed |