Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.38 |
| ▸ | GAA | P10253 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532357 | 0.87 | ALDH1A1 (0.38) | ALDH1A1MAPTGAARAB9ASMN1; SMN2 | |
| SCHEMBL9424525 | 0.85 | ALDH1A1 (0.37) | ALDH1A1MAPTGAANPC1RAB9A | |
| SCHEMBL9424532 | 0.85 | ALDH1A1 (0.37) | ALDH1A1MAPTGAANPC1RAB9A | |
| SCHEMBL9533258 | 0.83 | ALDH1A1 (0.38) | ALDH1A1MAPTGAANPC1RAB9A | |
| SCHEMBL9533260 | 0.83 | ALDH1A1 (0.38) | ALDH1A1MAPTGAANPC1RAB9A | |
| SCHEMBL9531370 | 0.81 | ALDH1A1 (0.35) | ALDH1A1GAARAB9AKDM4ECYP3A4 | |
| SCHEMBL9531329 | 0.81 | ALDH1A1 (0.35) | ALDH1A1GAARAB9AKDM4ECYP3A4 | |
| SCHEMBL9060038 | 0.80 | MAPT (0.38) | ALDH1A1MAPTGAANPC1RAB9A | |
| SCHEMBL27301993 | 0.80 | NPC1 (0.38) | ALDH1A1MAPTGAANPC1RAB9A | |
| SCHEMBL9060361 | 0.72 | ALDH1A1 (0.38) | ALDH1A1MAPTGAARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0385038-B1 | ORTHO-SUBSTITUTED PHENYL AMIDINE AND PHENYL GUANIDINE DERIVATIVES AND ANTIDIABETIC OR HYPOGLYCAEMIC AGENTS CONTAINING THEM | The Boots Company PLC (GB) | 1993-06-02 | — | — | EP | disclosed |