Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 3/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20636784 | 0.71 | KIF20B (0.48) | HTTMAPTKDM4EPOLBALDH1A1 | |
| SCHEMBL9868847 | 0.71 | CSNK2A1 (0.47) | CSNK2A1CSNK2A2CSNK2BHSD17B10HTT | |
| SCHEMBL7558600 | 0.70 | CSNK2A1 (0.40) | CSNK2A1CSNK2A2CSNK2BHSD17B10HTT | |
| SCHEMBL9534185 | 0.69 | CSNK2A1 (0.36) | CSNK2A1CSNK2A2CSNK2BMAPTPOLB | |
| SCHEMBL9865741 | 0.68 | HPGD (0.42) | CSNK2A1CSNK2A2CSNK2BHSD17B10HTT | |
| SCHEMBL29362247 | 0.66 | CSNK2A1 (0.36) | CSNK2A1CSNK2A2CSNK2BHSD17B10HTT | |
| SCHEMBL29138004 | 0.66 | CSNK2A1 (0.36) | CSNK2A1CSNK2A2CSNK2BHSD17B10HTT | |
| SCHEMBL12843366 | 0.65 | CSNK2A1 (0.39) | CSNK2A1CSNK2A2CSNK2BHSD17B10HTT | |
| SCHEMBL8183601 | 0.65 | HTT (0.56) | CSNK2A1CSNK2A2CSNK2BHSD17B10HTT | |
| SCHEMBL20092266 | 0.65 | HSD17B10 (0.40) | CSNK2A1CSNK2A2CSNK2BHSD17B10HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0348872-B1 | FUSED DIHYDROXYQUINOXALINES AND THEIR USE AS GLUTAMATE ANTAGONISTS | NOVO NORDISK A/S (DK) | 1993-09-29 | — | — | EP | disclosed |
| US-5109001-A | Treating hyperactivity of excitatory neurotransmitters | NOVO NORDISK A/S (DK) | 1992-04-28 | — | — | US | disclosed |
| US-5079250-A | TRICYCLIC HETEROCYCLIC DIOLS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-01-07 | — | — | US | disclosed |
| US-5075306-A | Nervous system, psychological disorders | NOVO NORDISK A/S (DK) | 1991-12-24 | — | — | US | disclosed |
| US-5057516-A | Nervous system disorders | NOVO NORDISK A/S (DK) | 1991-10-15 | — | — | US | disclosed |
| US-4977155-A | Nervous system disorders | A/S FERROSAN (DK) | 1990-12-11 | — | — | US | disclosed |
| EP-0348872-A1 | Fused dihydroxyquinoxalines and their use as glutamate antagonists | NOVO NORDISK A/S (DK) | 1990-01-03 | — | — | EP | disclosed |