Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL909656 | 0.91 | TSHR (0.36) | TSHRFFAR4ALDH1A1LMNAHPGD | |
| SCHEMBL9537849 | 0.88 | TSHR (0.42) | TSHRSMN1; SMN2 | |
| SCHEMBL910148 | 0.85 | TSHR (0.36) | TSHRFFAR4ALDH1A1LMNAHPGD | |
| SCHEMBL7850191 | 0.85 | FFAR4 (0.40) | TSHRFFAR4ALDH1A1SMN1; SMN2PTGS2 | |
| Metosulam SCHEMBL23302655 | 0.83 | TSHR (0.41) | TSHRFFAR4ALDH1A1LMNAHPGD | |
| Metosulam SCHEMBL29516826 | 0.83 | TSHR (0.41) | TSHRFFAR4ALDH1A1LMNAHPGD | |
| Metosulam SCHEMBL55076 | 0.83 | TSHR (0.41) | TSHRFFAR4ALDH1A1LMNAHPGD | |
| SCHEMBL8335333 | 0.82 | TSHR (0.32) | TSHRFFAR4ALDH1A1LMNAPTGS2 | |
| SCHEMBL9535324 | 0.79 | TSHR (0.42) | TSHRSMN1; SMN2 | |
| SCHEMBL9534479 | 0.78 | SMN1; SMN2 (0.34) | TSHRLMNASMN1; SMN2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0343752-B1 | Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamides, process for their preparation and intermediates | DOWELANCO (US) | 1993-12-01 | — | — | EP | disclosed |
| US-5163995-A | For use with grassy crops and soybeans | DOWELANCO (US) | 1992-11-17 | — | — | US | disclosed |
| US-5010195-A | From 5-alkoxy-1,2,4-triazolo(1,5-c)pyrimidine | THE DOW CHEMICAL COMPANY (US) | 1991-04-23 | — | — | US | disclosed |
| WO-1989011782-A1 | ALKOXY-1,2,4-TRIAZOLO[1,5-c]PYRIMIDINE-2-SULFONAMIDES, PROCESS FOR THEIR PREPARATION AND INTERMEDIATES | THE DOW CHEMICAL COMPANY (US) | 1989-12-14 | — | — | WO | disclosed |
| EP-0343752-A1 | Alkoxy-1,2,4-triazolo (1,5-c) pyrimidine-2-sulfonamides, process for their preparation and intermediates | DowElanco (US) | 1989-11-29 | — | — | EP | disclosed |