Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534388 | 1.00 | HTR6 (0.37) | HTR6KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9536315 | 0.88 | HTR6 (0.41) | HTR6KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9536312 | 0.88 | HTR6 (0.41) | HTR6KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9533895 | 0.85 | ADRA2A (0.47) | HTR6KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9533899 | 0.85 | ADRA2A (0.47) | HTR6KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9534646 | 0.81 | KMT2A (0.38) | HTR6KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9534638 | 0.81 | KMT2A (0.38) | HTR6KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9534428 | 0.79 | HTR6 (0.40) | HTR6KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9534421 | 0.79 | HTR6 (0.40) | HTR6KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL9535603 | 0.76 | ADRA1D (0.56) | HTR6KMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384676-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1993-11-10 | — | — | EP | disclosed |
| US-4981849-A | OBESITY, DIABETES, CARDIOVASCULAR DISORDERS, DEPRESSION | SMITHKLINE BEECHAM CORPORATION (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0384676-A1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |