Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 4/20 | 0.61 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.61 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.61 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.34 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533714 | 0.85 | ADRA1A (0.57) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL9535598 | 0.84 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL9535603 | 0.84 | ADRA1D (0.56) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL9534509 | 0.83 | ADRA2A (0.50) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL9533949 | 0.82 | ADRA1D (0.61) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL9535724 | 0.80 | ADRA2A (0.61) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL9534202 | 0.79 | ADRA2A (0.51) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL9533309 | 0.78 | ADRA1D (0.68) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL9534502 | 0.78 | ADRA2A (0.56) | ADRA1DADRA1AADRA1BADRA2AADRA2B | |
| SCHEMBL9533257 | 0.77 | ADRA2A (0.57) | ADRA1DADRA1AADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384677-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1993-12-01 | — | — | EP | claimed |
| EP-0384677-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1993-12-01 | — | — | EP | disclosed |
| US-4981848-A | CARDIOVASCULAR, HYPOTENSIVE, ANTIDEPRESSANT | SMITHKLINE BEECHAM CORPORATION (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0384677-A1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |