Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 5/20 | 0.49 |
| ▸ | KCNJ11 | Q14654 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11542408 | 0.74 | ALDH1A1 (0.42) | ABCC9KCNJ11ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL11542404 | 0.74 | ALDH1A1 (0.42) | ABCC9KCNJ11ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL9534597 | 0.72 | ALDH1A1 (0.47) | ABCC9KCNJ11ALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL4477801 | 0.69 | — | — | |
| SCHEMBL4477799 | 0.69 | — | — | |
| SCHEMBL11162280 | 0.67 | ABCC9 (0.47) | ABCC9KCNJ11ALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL11509173 | 0.67 | ALDH1A1 (0.42) | ABCC9KCNJ11ALDH1A1SMN1; SMN2 | |
| SCHEMBL11087993 | 0.64 | — | — | |
| SCHEMBL11087989 | 0.64 | — | — | |
| Pinacidil Anhydrous SCHEMBL1650693 | 0.64 | ABCC9 (1.00) | ABCC9KCNJ11ALDH1A1CYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0377528-B1 | Piperidines, process for their preparation and pharmaceutical compounds containing them | LIPHA (FR) | 1993-12-08 | — | — | EP | disclosed |
| US-5001134-A | Piperidines, processes of preparation and medications containing them | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1991-03-19 | — | — | US | disclosed |
| EP-0377528-A1 | Piperidines, process for their preparation and pharmaceutical compounds containing them | LIPHA, LYONNAISE INDUSTRIELLE PHARMACEUTIQUE (FR) | 1990-07-11 | — | — | EP | disclosed |