Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.48 |
| ▸ | EDNRA | P25101 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9144495 | 0.91 | KDM4E (0.58) | KDM4EMAPTHTTEDNRAHPGD | |
| SCHEMBL10758715 | 0.89 | KDM4E (0.58) | KDM4EMAPTHTTMAPK8EDNRA | |
| SCHEMBL9141602 | 0.89 | KDM4E (0.53) | KDM4EMAPTHTTEDNRAHPGD | |
| SCHEMBL9538268 | 0.86 | MAPK8 (0.52) | KDM4EMAPTMAPK8HPGDPKM | |
| SCHEMBL9535567 | 0.86 | PPARG (0.48) | MAPTHTTMAPK8EDNRAHPGD | |
| SCHEMBL9536815 | 0.86 | MAPK8 (0.51) | KDM4EMAPTMAPK8HPGDALDH1A1 | |
| SCHEMBL9144254 | 0.84 | KDM4E (0.47) | KDM4EMAPTHTTMAPK8EDNRA | |
| SCHEMBL9534868 | 0.84 | MEN1 (0.54) | KDM4EMAPTHTTMAPK8EDNRA | |
| SCHEMBL10652966 | 0.82 | KDM4E (0.51) | KDM4EMAPTHTTMAPK8EDNRA | |
| SCHEMBL9536907 | 0.82 | KDM4E (0.54) | KDM4EMAPTHTTMAPK8EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |