Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 5/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535567 | 0.90 | PPARG (0.48) | MAPK8PKMHPGDHSD17B10MAPT | |
| SCHEMBL10756621 | 0.88 | PPARG (0.53) | MAPK8KDM4EPKMPPARGLMNA | |
| SCHEMBL9538497 | 0.86 | MAPK8 (0.55) | MAPK8NR4A2KDM4EPKMHPGD | |
| SCHEMBL9534704 | 0.86 | KDM4E (0.53) | MAPK8KDM4EPKMHPGDHSD17B10 | |
| SCHEMBL9538268 | 0.86 | MAPK8 (0.52) | MAPK8KDM4EPKMHPGDHSD17B10 | |
| SCHEMBL10464433 | 0.82 | MAPK8 (0.57) | MAPK8NR4A2KDM4EPKMHPGD | |
| SCHEMBL10758409 | 0.81 | PPARG (0.60) | KDM4EMAPTPPARGLMNAFOLH1 | |
| SCHEMBL10761739 | 0.80 | MAPK8 (0.52) | MAPK8NR4A2KDM4EPKMHPGD | |
| SCHEMBL10656000 | 0.80 | MAPK8 (0.52) | MAPK8NR4A2KDM4EPKMHPGD | |
| SCHEMBL27286578 | 0.80 | MAPK8 (0.55) | MAPK8NR4A2KDM4EPKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |
| CN-1005974-B | Process for preparing acid indole compounds | 沃纳·兰伯特公司 | 1989-12-06 | — | — | CN | disclosed |
| US-4675332-A | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1987-06-23 | — | — | US | disclosed |
| EP-0186367-A2 | Acidic indole compounds and their use as antiallergy agents | WARNER-LAMBERT COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |