Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.66 |
| ▸ | HPGD | P15428 | 3/20 | 0.66 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | ERN1 | O75460 | 1/20 | 0.55 |
| ▸ | APAF1 | O14727 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | CASP6 | P55212 | 1/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.54 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23143203 | 0.88 | KDM4E (0.66) | KDM4EALDH1A1HPGDACMSDERN1 | |
| SCHEMBL504872 | 0.87 | CHEK1 (0.60) | KDM4EALDH1A1HPGDACMSDCHEK1 | |
| SCHEMBL29788086 | 0.87 | CHEK1 (0.60) | KDM4EALDH1A1HPGDACMSDCHEK1 | |
| SCHEMBL2770512 | 0.87 | ALDH1A1 (0.67) | KDM4EALDH1A1HPGDCHEK1APAF1 | |
| SCHEMBL14156931 | 0.86 | ESR1 (0.56) | KDM4EALDH1A1HPGDACMSDCHEK1 | |
| SCHEMBL8692896 | 0.84 | KDM4E (0.49) | KDM4EALDH1A1HPGDCHEK1APAF1 | |
| SCHEMBL17177740 | 0.83 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDCHEK1APAF1 | |
| SCHEMBL10459347 | 0.82 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDCHEK1APAF1 | |
| SCHEMBL617928 | 0.80 | ALDH1A1 (1.00) | KDM4EALDH1A1HPGDHSD17B10NPC1 | |
| SCHEMBL9537888 | 0.80 | MCL1 (0.62) | KDM4EALDH1A1HPGDACMSDCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0532531-A1 | PHENOL AND PYRIDINOL DERIVATIVES AS PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-03-24 | — | — | EP | disclosed |
| WO-1991017987-A1 | PHENOL AND PYRIDINOL DERIVATIVES AS PHARMACEUTICALS | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-11-28 | — | — | WO | disclosed |