SCHEMBL9534743

SCHEMBL9534743

CCCc1nc(C(=O)O)c(C(F)(F)F)n1Cc1ccc(OCc2cccc(C(=O)O)c2Cl)c(Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MRGPRX4 Q96LA9 8/20 0.48
PPARG P37231 5/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9531882 0.81 PPARG (0.46) PPARG
SCHEMBL9533202 0.75 CD274 (0.38) PPARG
SCHEMBL9042682 0.73 PPARG (0.46) PPARG
SCHEMBL9042339 0.72 MRGPRX4 (0.43) MRGPRX4
SCHEMBL9044992 0.72 PPARG (0.44) PPARG
SCHEMBL9044886 0.71 MRGPRX4 (0.46) MRGPRX4
SCHEMBL9532185 0.70 AGTR1 (0.48)
SCHEMBL9041440 0.70 PTGES (0.49)
SCHEMBL9196620 0.70 EDNRB (0.62)
SCHEMBL9044003 0.70 MRGPRX4 (0.46) MRGPRX4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0515548-A4 IMIDAZOLE ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT 1993-03-10 EP disclosed
EP-0515548-A1 IMIDAZOLE ANGIOTENSIN II ANTAGONISTS INCORPORATING A SUBSTITUTED BENZYL ELEMENT MERCK & CO. INC. (US) 1992-12-02 EP disclosed