Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VDR | P11473 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 6/20 | 0.39 |
| ▸ | MAOB | P27338 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9385939 | 0.84 | ALDH1A1 (0.41) | VDRALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL11381634 | 0.84 | ALDH1A1 (0.39) | ALDH1A1HPGDSMN1; SMN2GLAADRB3 | |
| SCHEMBL11380495 | 0.84 | ALDH1A1 (0.36) | VDRALDH1A1KDM4ESMN1; SMN2GLA | |
| SCHEMBL9384498 | 0.83 | ALDH1A1 (0.46) | VDRALDH1A1HPGDSMN1; SMN2GLA | |
| SCHEMBL9654091 | 0.81 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2GLATSHRHTR2A | |
| SCHEMBL11378856 | 0.81 | ALDH1A1 (0.35) | MAOAMAOBALDH1A1SMN1; SMN2GLA | |
| SCHEMBL9652974 | 0.80 | ALDH1A1 (0.38) | VDRALDH1A1KDM4EHPGDSMN1; SMN2 | |
| SCHEMBL9651024 | 0.80 | HTR2A (0.44) | ALDH1A1SMN1; SMN2GLAADRB3TSHR | |
| SCHEMBL7091814 | 0.80 | BRD4 (0.42) | MAOAMAOBALDH1A1HTTGLA | |
| SCHEMBL6074729 | 0.80 | BRD4 (0.42) | MAOAMAOBALDH1A1HTTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254595-A | Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them | ELF SANOFI (FR) | 1993-10-19 | — | — | US | disclosed |
| EP-0375560-B1 | ARYLOXYPROPANOLAMINOTETRALINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ELF SANOFI (FR) | 1993-05-12 | — | — | EP | disclosed |