Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | CTSB | P07858 | 4/20 | 0.43 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | CASP6 | P55212 | 3/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819646 | 0.84 | HSP90AA1 (0.47) | HSP90AA1HSP90AB1MAPTALDH1A1KDM4E | |
| SCHEMBL9670886 | 0.82 | MAPT (0.65) | HSP90AA1HSP90AB1MAPTALDH1A1KDM4E | |
| SCHEMBL9535035 | 0.79 | CTSB (0.41) | HSP90AA1HSP90AB1MAPTALDH1A1MEN1 | |
| SCHEMBL9533842 | 0.79 | TXNRD1 (0.55) | HSP90AA1HSP90AB1MAPTALDH1A1MEN1 | |
| SCHEMBL9532539 | 0.79 | MEN1 (0.48) | HSP90AA1HSP90AB1MEN1KMT2AIDO1 | |
| Dnqx SCHEMBL1258964 | 0.78 | POLB (0.57) | HSP90AA1HSP90AB1MAPTALDH1A1KDM4E | |
| SCHEMBL9534040 | 0.76 | MAPT (0.40) | HSP90AA1HSP90AB1MAPTALDH1A1KDM4E | |
| SCHEMBL9534461 | 0.76 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1MAPTALDH1A1KDM4E | |
| SCHEMBL9669439 | 0.74 | HPRT1 (0.51) | HSP90AA1HSP90AB1MAPTALDH1A1KDM4E | |
| SCHEMBL6108346 | 0.73 | PTPN11 (0.64) | HSP90AA1HSP90AB1MAPTALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5079250-A | TRICYCLIC HETEROCYCLIC DIOLS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-01-07 | — | — | US | claimed |
| EP-0348872-B1 | FUSED DIHYDROXYQUINOXALINES AND THEIR USE AS GLUTAMATE ANTAGONISTS | NOVO NORDISK A/S (DK) | 1993-09-29 | — | — | EP | disclosed |
| US-5109001-A | Treating hyperactivity of excitatory neurotransmitters | NOVO NORDISK A/S (DK) | 1992-04-28 | — | — | US | disclosed |
| US-5079250-A | TRICYCLIC HETEROCYCLIC DIOLS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-01-07 | — | — | US | disclosed |
| US-5075306-A | Nervous system, psychological disorders | NOVO NORDISK A/S (DK) | 1991-12-24 | — | — | US | disclosed |
| US-5057516-A | Nervous system disorders | NOVO NORDISK A/S (DK) | 1991-10-15 | — | — | US | disclosed |
| US-4977155-A | Nervous system disorders | A/S FERROSAN (DK) | 1990-12-11 | — | — | US | disclosed |
| EP-0348872-A1 | Fused dihydroxyquinoxalines and their use as glutamate antagonists | NOVO NORDISK A/S (DK) | 1990-01-03 | — | — | EP | disclosed |