Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | TP53 | P04637 | 6/20 | 0.60 |
| ▸ | THRB | P10828 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ELANE | P08246 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | EDNRA | P25101 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10758715 | 0.88 | KDM4E (0.58) | MAPTSMN1; SMN2KDM4EHTTALDH1A1 | |
| SCHEMBL10761647 | 0.85 | KDM4E (0.64) | MAPTTP53SMN1; SMN2KDM4EHTT | |
| SCHEMBL9534868 | 0.85 | MEN1 (0.54) | MAPTTP53THRBSMN1; SMN2KDM4E | |
| SCHEMBL9146455 | 0.82 | MEN1 (0.58) | MAPTTP53THRBSMN1; SMN2KDM4E | |
| SCHEMBL9143441 | 0.81 | MEN1 (0.54) | MAPTTP53THRBSMN1; SMN2KDM4E | |
| SCHEMBL10652966 | 0.79 | KDM4E (0.51) | MAPTTP53KDM4EHTTALDH1A1 | |
| SCHEMBL9536907 | 0.79 | KDM4E (0.54) | MAPTTP53SMN1; SMN2KDM4EHTT | |
| SCHEMBL9538371 | 0.78 | MAPK8 (0.48) | MAPTKDM4EHTTKMT2AMEN1 | |
| SCHEMBL9538611 | 0.78 | MAPK8 (0.48) | MAPTKDM4EHTTKMT2AMEN1 | |
| SCHEMBL9534704 | 0.78 | KDM4E (0.53) | MAPTTP53SMN1; SMN2KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0186367-B1 | ACIDIC INDOLE COMPOUNDS AND THEIR USE AS ANTIALLERGY AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-03-03 | — | — | EP | disclosed |