Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538656 | 0.73 | PLK1 (0.39) | PLK1CSNK2A1PLK3 | |
| SCHEMBL9220489 | 0.71 | DRD4 (0.47) | MMP12PLK1CSNK2A1PLK3 | |
| SCHEMBL9534036 | 0.69 | CSNK2A1 (0.35) | PLK1CSNK2A1PLK3 | |
| SCHEMBL9216050 | 0.69 | DRD4 (0.56) | MMP12PLK1CSNK2A1PLK3 | |
| SCHEMBL9214111 | 0.68 | PLK1 (0.34) | PLK1CSNK2A1PLK3 | |
| SCHEMBL9534430 | 0.61 | PLK1 (0.56) | PLK1CSNK2A1PLK3 | |
| SCHEMBL9535703 | 0.61 | PLK1 (0.61) | PLK1CSNK2A1PLK3 | |
| SCHEMBL9534532 | 0.60 | PLK1 (0.54) | PLK1CSNK2A1PLK3 | |
| Hydrochloric Acid SCHEMBL9534437 | 0.59 | PLK1 (0.59) | PLK1CSNK2A1PLK3 | |
| SCHEMBL9533936 | 0.58 | PLK1 (0.74) | PLK1CSNK2A1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276835-B1 | PYRAZOLOTHIOPYRANOPYRAZOLES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0276835-A1 | Pyrazolothiopyranopyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734431-A | Thiopyranodipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |