Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538656 | 0.73 | PLK1 (0.39) | CSNK2A1PLK1PLK3 | |
| SCHEMBL9533151 | 0.73 | AURKA (0.31) | CSNK2A1AURKACHEK2CDK1PIM1 | |
| SCHEMBL9210952 | 0.71 | LTK (0.45) | CSNK2A1AURKACHEK2PIM1CDK2 | |
| SCHEMBL9218064 | 0.68 | PLK1 (0.34) | CSNK2A1PLK1PLK3 | |
| SCHEMBL9538373 | 0.64 | PLK1 (0.46) | CSNK2A1CDK2PLK1PLK3 | |
| SCHEMBL9534430 | 0.61 | PLK1 (0.56) | CSNK2A1PLK1PLK3 | |
| SCHEMBL9535703 | 0.61 | PLK1 (0.61) | CSNK2A1PLK1PLK3 | |
| SCHEMBL9533873 | 0.60 | PLK1 (0.54) | CSNK2A1CDK2PLK1PLK3 | |
| Hydrochloric Acid SCHEMBL9534437 | 0.59 | PLK1 (0.59) | CSNK2A1PLK1PLK3 | |
| Hydrochloric Acid SCHEMBL9221777 | 0.57 | PLK1 (0.49) | CSNK2A1PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276835-B1 | PYRAZOLOTHIOPYRANOPYRAZOLES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-17 | — | — | EP | claimed |
| US-4734431-A | Thiopyranodipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | claimed |
| EP-0382629-B1 | Aminoalkoxyphenyl derivatives, process for their preparation and compositions containing them | SANOFI ELF (FR) | 1993-11-24 | — | — | EP | disclosed |
| EP-0276835-B1 | PYRAZOLOTHIOPYRANOPYRAZOLES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0382629-A1 | Aminoalkoxyphenyl derivatives, process for their preparation and compositions containing them | ELF SANOFI (FR) | 1990-08-16 | — | — | EP | disclosed |
| EP-0276835-A1 | Pyrazolothiopyranopyrazoles | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4734431-A | Thiopyranodipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |