Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534036 | 0.73 | CSNK2A1 (0.35) | PLK1CSNK2A1PLK3 | |
| SCHEMBL9211095 | 0.67 | PLK1 (0.49) | PLK1CSNK2A1PLK3DRD2DRD4 | |
| SCHEMBL9534430 | 0.66 | PLK1 (0.56) | PLK1CSNK2A1PLK3DRD2HIF1A | |
| Hydrochloric Acid SCHEMBL9216167 | 0.66 | PLK1 (0.47) | PLK1CSNK2A1PLK3DRD2DRD4 | |
| SCHEMBL9535703 | 0.65 | PLK1 (0.61) | PLK1CSNK2A1PLK3DRD2DRD4 | |
| SCHEMBL10798104 | 0.65 | DRD2 (0.47) | DRD2DRD4HIF1A | |
| Hydrochloric Acid SCHEMBL9534437 | 0.63 | PLK1 (0.59) | PLK1CSNK2A1PLK3DRD2DRD4 | |
| SCHEMBL19153460 | 0.63 | PLK1 (0.44) | PLK1CSNK2A1PLK3DRD2DRD4 | |
| SCHEMBL10368994 | 0.61 | MMP12 (0.57) | DRD2DRD4 | |
| SCHEMBL9211138 | 0.59 | PLK1 (0.44) | PLK1CSNK2A1PLK3DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276835-B1 | PYRAZOLOTHIOPYRANOPYRAZOLES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4734431-A | Thiopyranodipyrazoles and their use as bronchodilators | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-03-29 | — | — | US | disclosed |