SCHEMBL9534894

SCHEMBL9534894

CCCC(=O)N1CCN([C]=O)C1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 1/20 0.41
CHRNA3 P32297 1/20 0.41
CHRNA4 P43681 1/20 0.41
CHRNB3 Q05901 1/20 0.41
CHRNA6 Q15825 1/20 0.41
L3MBTL1 Q9Y468 2/20 0.39
MEN1 O00255 4/20 0.38
KMT2A Q03164 4/20 0.38
TDP1 Q9NUW8 2/20 0.38
GNAI3 P08754 2/20 0.38
GNAI1 P63096 2/20 0.38
MAPT P10636 6/20 0.37
USP2 O75604 2/20 0.36
ALDH1A1 P00352 2/20 0.36
KDM4E B2RXH2 1/20 0.36
LMNA P02545 1/20 0.36
CYP3A4 P08684 1/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36
POLB P06746 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9536777 0.89 L3MBTL1 (0.49) L3MBTL1MEN1KMT2ATDP1GNAI3
SCHEMBL9532272 0.89 L3MBTL1 (0.46) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL674671 0.77
SCHEMBL10663507 0.77 L3MBTL1 (0.58) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL7036074 0.75 GNAI3 (0.63) L3MBTL1MEN1KMT2ATDP1GNAI3
SCHEMBL11125464 0.74 L3MBTL1 (0.55) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL9533374 0.74 CYP1A2 (0.44) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL14532731 0.73 CHRNB2 (0.54) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL8984773 0.72 BLM (0.46) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6
SCHEMBL9534899 0.70 CHRNB2 (0.41) CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0277836-B1 THIAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE Sankyo Company Limited (JP) 1993-06-02 EP disclosed
US-5104888-A Anticholesterol or antidiabetic agents SANKYO COMPANY, LIMITED (JP) 1992-04-14 US disclosed
EP-0207581-B1 THIAZOLIDINE DERIVATIVES, THEIR PREPARATION AND USE SANKYO COMPANY LIMITED (JP) 1990-09-12 EP disclosed
US-4873255-A REDUCE BLOOD GLUCOSE AND BLOOD LIPID LEVELS SANKYO COMPANY LIMITED (JP) 1989-10-10 US disclosed
EP-0277836-A1 Thiazolidinone derivatives, their preparation and their use Sankyo Company Limited (JP) 1988-08-10 EP disclosed
EP-0207581-A2 Thiazolidine derivatives, their preparation and use SANKYO COMPANY LIMITED (JP) 1987-01-07 EP disclosed