Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SSTR5 | P35346 | 4/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 5/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.43 |
| ▸ | EED | O75530 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HLA-A | P04439 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9698301 | 0.85 | SSTR5 (0.66) | SSTR5KCNH2NR4A2HRH1CYP2D6 | |
| SCHEMBL9536246 | 0.85 | TSHR (0.49) | SSTR5KCNH2NR4A2RAB9AHRH1 | |
| SCHEMBL9536807 | 0.83 | SSTR5 (0.50) | SSTR5KCNH2NR4A2RAB9AHRH1 | |
| SCHEMBL10549525 | 0.82 | RAB9A (0.55) | SSTR5KCNH2NR4A2RAB9AHRH1 | |
| SCHEMBL11017092 | 0.81 | SSTR5 (0.49) | SSTR5KCNH2NR4A2RAB9AHRH1 | |
| SCHEMBL9537110 | 0.81 | SSTR5 (0.49) | SSTR5KCNH2NR4A2RAB9AHRH1 | |
| SCHEMBL9539506 | 0.81 | SSTR5 (0.44) | SSTR5KCNH2NR4A2RAB9AHRH1 | |
| Fumaric Acid SCHEMBL10553479 | 0.81 | HRH1 (0.46) | SSTR5KCNH2NR4A2HRH1HRH4 | |
| SCHEMBL9536847 | 0.80 | KCNH2 (0.49) | SSTR5KCNH2NR4A2RAB9AHRH1 | |
| SCHEMBL10547535 | 0.80 | KCNH2 (0.54) | SSTR5KCNH2NR4A2RAB9AHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | claimed |
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |