Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 11/20 | 0.56 |
| ▸ | PDE1B | Q01064 | 11/20 | 0.56 |
| ▸ | PDE1C | Q14123 | 11/20 | 0.56 |
| ▸ | PDE2A | O00408 | 10/20 | 0.56 |
| ▸ | CFTR | P13569 | 2/20 | 0.48 |
| ▸ | PDE5A | O76074 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | SCN1A | P35498 | 1/20 | 0.48 |
| ▸ | PDE6C | P51160 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.48 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534747 | 0.79 | PIK3CD (0.43) | CYP1A2TSHRPDE4AADORA1PDE4B | |
| SCHEMBL9038623 | 0.78 | PDE1A (0.54) | PDE1APDE1BPDE1CPDE2ACFTR | |
| SCHEMBL10371053 | 0.77 | PDE1A (0.56) | PDE1APDE1BPDE1CPDE2ACFTR | |
| SCHEMBL9535691 | 0.74 | ALDH1A1 (0.45) | CYP1A2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10542962 | 0.73 | CFTR (0.54) | PDE1APDE1BPDE1CPDE2ACFTR | |
| SCHEMBL9534400 | 0.73 | PDE1A (0.51) | PDE1APDE1BPDE1CPDE2ACFTR | |
| SCHEMBL4811164 | 0.68 | ALDH1A1 (0.60) | PDE1APDE1BPDE1CPDE2ACFTR | |
| SCHEMBL2457446 | 0.67 | PDE1A (0.52) | PDE1APDE1BPDE1CPDE2ACFTR | |
| SCHEMBL8229445 | 0.66 | AGER (0.62) | CYP1A2TSHRALDH1A1LMNASMN1; SMN2 | |
| Isobutylmethylxanthine SCHEMBL7637581 | 0.66 | PDE4A (0.94) | PDE1APDE1BPDE1CPDE2ACFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0244352-B1 | Pyrido[4,3-d]pyrimidine derivatives | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1993-03-31 | — | — | EP | claimed |
| US-4808618-A | ANTIALLERGENS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1989-02-28 | — | — | US | claimed |
| EP-0244352-B1 | Pyrido[4,3-d]pyrimidine derivatives | NIPPON ZOKI PHARMACEUTICAL CO. LTD. (JP) | 1993-03-31 | — | — | EP | disclosed |
| US-4808618-A | ANTIALLERGENS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1989-02-28 | — | — | US | disclosed |