Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.40 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.40 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538842 | 0.87 | SSTR5 (0.52) | ENPP2SSTR5CYP2D6RAB9A | |
| SCHEMBL9536663 | 0.87 | RAB9A (0.55) | LMNAHTTMAPTTP53SMN1; SMN2 | |
| SCHEMBL9537238 | 0.85 | KCNH2 (0.43) | ENPP2HPGDLMNAHTTMAPT | |
| SCHEMBL9535904 | 0.83 | KCNH2 (0.54) | ENPP2HPGDLMNAHTTMAPT | |
| SCHEMBL9537190 | 0.81 | PRMT3 (0.44) | PRMT3CARM1PRMT6PRMT1PRMT8 | |
| Oxalic Acid SCHEMBL9537934 | 0.81 | HRH1 (0.56) | ENPP2HPGDLMNAHTTMAPT | |
| Oxalic Acid SCHEMBL9537337 | 0.81 | ENPP2 (0.44) | ENPP2HPGDLMNAHTTMAPT | |
| Oxalic Acid SCHEMBL9537930 | 0.81 | HRH1 (0.56) | ENPP2HPGDLMNAHTTMAPT | |
| Oxalic Acid SCHEMBL9537334 | 0.81 | ENPP2 (0.44) | ENPP2HPGDLMNAHTTMAPT | |
| SCHEMBL9537085 | 0.80 | SLC6A9 (0.58) | ENPP2LMNAMAPTTP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |